My thoughts...
You say a sump? or a refug...?
If you run a sump you could sustain higher flow rates thru the sump.
If you run a refug you would want a lower flow rate so macro algae, live rock, copepods and your deep sand bed have more time to process the water. A refug is just a living filter so you don't want to flush your filter with to much flow or it just doesn't have time to process the water correctly.
I have a 95g display tank...plumbed to my basement where i have two additional refug's and a 180 frag tank. I run my water cycling very slow but my display tank up stairs has alot of movement by vertech pumps. I don't cycle thru the recommended 10/times per hour. But do way over 10/times per hour in water movement within the tank itself...
Hope that makes sense and helps. It works for me so it should work for you!
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