SF is only an hour away - and I spend so little time there! I hate city traffic, and parking can be a real pain, so not renting a car isn't such a bad thing.
Must sees:
The Golden Gate and Bay Bridges
Alcatraz
Downtown (most of the stores should have their Christmas decorations up - gorgeous)
If you REALLY want to do the whole tourist thing, here you go:
San Francisco Tours, San Francisco Sightseeing Tours, San Francisco Bus Tours
Yes - bring warm clothes. So far we've had very little rain, but it is starting to get a bit chilly (that's low 60's for us Californians!)